1. Histology:
- the renal arteries of the small and medium-caliber (muscular type), segmentally, have a brightly eosinophilic wall as a result of the formation of a band of fibrinoid necrosis located along the entire perimeter, i.e. circularly;
- there is cellular infiltration in the stroma around the foci of destruction of the vessel wall, represented by macrophages, lymphocytes and neutrophils (destructive proliferative arteritis);
- in the future, alterative-proliferative changes result in sclerosis of the artery wall and their nodular thickening;
- part of the glomeruli has undergone atrophy and sclerosis, protein dystrophy is observed in the epithelium of the tubules.
2. Anatomy:
- the kidneys are reduced, dense, finely rounded, mottled; the vessels are convoluted, knobby; in the acute period, there are infarcts, hemorrhages, and the kidney parenchyma is mottled.
3. Clinical manifestations:
- in the process of primary renal shrinkage, symptoms of chronic renal failure increase, in the acute period - hematuria, pain in the lumbar region.
4. Draw and sign:
- 1 - fibrinoid necrosis of the arterial wall,
- 2 - pronounced mononuclear infiltration around the vessels and in the stroma,
- 3 - glomerular sclerosis.